Farming Differentiation in the Rural-urban Interface of the Middle Mountains, Nepal: Application of Analytic Hierarchy Process (AHP)Modeling

This article investigates the dominant factors of farming differentiation in the rural-urban interface of the densely populated Kathmandu Valley, using the Analytic Hierarchy Process (AHP) modeling. The rural-urban interface in the Kathmandu Valley is an important vegetable production pocket which supplies a large amount of the vegetables in the city core. While subsistence farming in the rural area is characterized by a system which integrates livestock and forestry with agriculture, the intensification in the urban fringe is characterized by triple crop rotations and market-oriented intensive vegetable production. Seven factors which were supposed to cause farming variation in the interface were incorporated in the AHP framework and then subjected to the farmers’ judgment in distinctly delineated three farming zones. These factors played crucial yet differing roles in different farming zones. Inaccessibility and use of local resources; higher yield and accessibility and agro-ecological consideration and quality production are the key impacting factors of subsistence, commercial inorganic and smallholder organic farming respectively. The quantification of such factors of farming differentiation through AHP is an important piece of information that will contribute in modeling farming in the rural-urban interface of developing countries which are characterized by a high diversity of farming practices and are undergoing a rapid change in the land use pattern

SOCIO-ECONOMIC AND ENVIRONMENTAL ASPECTS OF FARMING PRACTICES IN THE PERI-URBAN HINTERLANDS OF NEPAL

Spatial location of the farm households shapes farming practices and livelihoods of the farmers. Many socio-economic variables have strong spatial relations that would otherwise be missed by data aggregation at household level. Geographic Information System (GIS)provides display and analysis of socio-economic data that may be fundamental for many social scientists to understand socio-economic reality influenced by geographical position of the farm households. Present article aims at integrating socio-economic data into GIS environment to examine spatial relation in the resource availability and use employing spatial and random sampling techniques. Result demonstrates the variation in the socioeconomic attributes along the spatial gradient which is mainly related to the infrastructures such as road, market and improved agro-inputs. While households with better access to these infrastructures have tendency to use more agro-chemicals, have larger family, land holding and livestock units, better off-farm opportunities, commercial farming orientation and hence higher family income; opposite is true for the households with poor access to these infrastructures. Peri-urban farmlands, wherever agro-chemicals are applied imprudently, faces the problems of agro-ecological degradation while rural subsistence farming faces the problem of spatial poverty

Urban demands for organic tomatoes in the Kathmandu Valley, Nepal

This paper presents the willingness to pay for organic tomatoes by the consumers in urban areas of Nepal. It further makes an analysis of consumer preferences to this vegetables using conjoint modeling

High-resolution isotopic evidence of specialised cattle herding in the European Neolithic.

Peer reviewe

Sustainable change: long-term efforts toward developing a learning organization

Globalization and intensified competition require organizations to change and adapt to dynamic environments in order to stay competitive. This article describes a longitudinal action research study supporting the strategic change of a trading company. The strategic change was accompanied by planned changes in organizational structures and processes, management systems, emerging changes in leadership, and organization members’ attitudes and behaviors, and it was supported by management development activities. Longitudinal data over a 4-year period including participant observation and interviews reveal that a systemic approach, a learning and becoming perspective toward change, trust, an appropriate role perception, and the specific use of management instruments contribute to sustained change that resulted in performance improvements and a move toward a learning organization. We conclude with implications for strategic change and suggestions for further research in this area

Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy

Multifocal motor neuropathy is an immune mediated disease presenting with multifocal muscle weakness and conduction block. IgM auto-antibodies against the ganglioside GM1 are detectable in about 50% of the patients. Auto-antibodies against the paranodal proteins contactin-1 and neurofascin-155 and the nodal protein neurofascin-186 have been detected in subgroups of patients with chronic inflammatory demyelinating polyneuropathy. Recently, auto-antibodies against neurofascin-186 and gliomedin were described in more than 60% of patients with multifocal motor neuropathy. In the current study, we aimed to validate this finding, using a combination of different assays for auto-antibody detection. In addition we intended to detect further auto-antibodies against paranodal proteins, specifically contactin-1 and neurofascin-155 in multifocal motor neuropathy patients’ sera. We analyzed sera of 33 patients with well-characterized multifocal motor neuropathy for IgM or IgG anti-contactin-1, anti-neurofascin-155 or -186 antibodies using enzyme-linked immunosorbent assay, binding assays with transfected human embryonic kidney 293 cells and murine teased fibers. We did not detect any IgM or IgG auto-antibodies against contactin-1, neurofascin-155 or -186 in any of our multifocal motor neuropathy patients. We conclude that auto-antibodies against contactin-1, neurofascin-155 and -186 do not play a relevant role in the pathogenesis in this cohort with multifocal motor neuropathy

Hydrogen ion dynamics and the Na+/H+ exchanger in cancer angiogenesis and antiangiogenesis

Tumour angiogenesis and cellular pH regulation, mainly represented by Na+/H+ antiporter exchange, have been heretofore considered unrelated subfields of cancer research. In this short review, the available experimental evidence relating these areas of modern cancer research is introduced. This perspective also helps to design a new approach that facilitates the opening and development of novel research lines oriented towards a rational incorporation of anticancer drugs into more selective and less toxic therapeutic protocols. The final aim of these efforts is to control cancer progression and dissemination through the control of tumour angiogenesis. Finally, different antiangiogenic drugs that can already be clinically used to this effect are briefly presented